Gout

Causes

The underlying cause of gout is different from those things that trigger a gout attack. Gout is the result of excess uric acid in the body, a condition called hyperuricemia.

Uric acid is a substance that normally forms when the body breaks down purines, which are found in human cells and in many foods. Uric acid is transported by the blood to the kidneys and eliminated in the urine. However, some people either overproduce uric acid or they produce a normal amount, but their kidneys can’t process it efficiently and an excess of uric acid builds up. Some, but not all, of those people may develop gout.

Lifestyle factors, such as a diet high in certain high-purine foods, obesity and excessive alcohol use – especially heavy beer consumption – also can contribute to development of hyperuricemia and gout.

痛風的原因，不同引發痛風的。

痛風是身體過量尿酸，尿酸是正常人有的，過多才有事。尿酸通過血液運送到腎臟並在尿液中消除。 尿酸高不一定會有痛風。

生活方式因素，如某些

• 高嘌呤食物的飲食，
• 肥胖和
• 過量的酒精 - 重度啤酒

Triggers

• Medical or health triggers of gout:
• Medications: diuretics, cyclosporin, chemotherapy
• severe illness: Surgery or sudden, Infection
• Lifestyle triggers of gout:
• Crash diets and fasting
• Drinking too much alcohol
• Eating large portions of certain foods high in purines (red meats or shellfish)
• Dehydration (not getting enough fluids)
• Sweet sodas

Side effects:

Colchicine

(GI) diarrehoea, nausea, vomiting, GI bleed

Skin rash

Rarely, bone marrow suppression; peripheral neuritis, myopathy, rhabdomyolysis

Febuxostat

(GI) nausea, diarrhoea, constipation, abdominal pain